The Francis Crick Institute – High Throughput Screening facility

In April 2015 London Research Institute of Cancer Research UK officially became part of the Francis Crick Institute, a consortium of six of the UK’s most successful scientific and academic organisations – the Medical Research Council, Cancer Research UK, the Wellcome Trust, UCL (University College London), Imperial College London and King’s College London.  Some 1200 scientists will be located in a new purpose-built building in central London by 2016.  The Francis Crick Institute is an inter-disciplinary medical research institute. Its work will help understand why disease develops and find new ways to treat, diagnose and prevent illnesses such as cancer, heart disease and stroke, infections, and neurodegenerative diseases. By combining specialist knowledge, expertise and resources from each of these organisations, the Francis Crick Institute will encourage ground-breaking research across a range of scientific disciplines and help make sure that laboratory discoveries are turned into treatments as quickly as possible.  The High Throughput Screening facility is one of the core technology platforms of this new institute facilitating and enabling large scale RNAi screens, cell-based screens with well-characterised small molecule collections, CrispR deletion screens and yeast deletion screens across an even broader range of disciplines than hitherto but with the same close collaboration with individual research groups from the very inception of a project, through assay development and screening up to the production of the final list of validated hits and beyond.


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Principal Disease Indication(s)

Oncology, Infectious Diseases, Immunology


Platform(s)

Genome-wide human, mouse and Drosophila RNAi, drug repurposing, Fragments, CRISPR, Yeast deletion screening


Technology(ies):

High Content microscopy, HTS plate reader


Funding sources:

Cancer Research UK, MRC, Wellcome Trust, UCL, Imperial College London and Kings College London


Personnel:

4


Number of Screens / year (any size):

15-25


Medicinal Chemistry Follow-up:

NO


Contact Details

Michael Howell

Phone: +44 20 7269 3170
crick.ac.uk

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Getting there

Address: 215 Euston Road, Kings Cross, London NW1 2BE, UK
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