University of Sheffield – RNAi Screening Facility (SRSF)

Based at the University of Sheffield, our facility provides specialist equipment to assist the wider scientific community in carrying out high-throughput RNAi screens with Drosophila cells. We offer either pre-aliquoted whole genome RNAi libraries or sub-libraries of target probes. We support both plate reader assays, high-content microscopy as well as the equipment needed to process these samples in a high-throughput fashion. This can either be used to identify genes involved in disease representing future drug targets, or to identify genes involved in biological processes.


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Principal Disease Indication(s)

Oncology, Parkinson’s Disease, Myeloproliferative Neoplasms


Genome-wide Drosophila RNAi, Human siRNA, small molecules


HCI, MPA, HTS plate reader

Funding sources:

Wellcome Trust, Yorkshire Cancer Research, University of Sheffield



Number of Screens / year (any size):


Medicinal Chemistry Follow-up:


Contact Details

Dr Stephen Brown

Phone: +44 (0)114 222 3690

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Getting there

Address: 297 Western Bank, Sheffield, South Yorkshire S10 2TJ, UK
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