University of Sussex – Translational Drug Discovery Group

The Translational Drug Discovery Group (TDDG) was established in 2011 as part of a strategic investment by the University of Sussex in the School of Life Sciences. The group comprises medicinal chemistry and molecular pharmacology laboratories and aims to translate a fundamental understanding of disease processes and molecular targets into novel drugs.  Research is currently focussed on:

Oncology – working with the Sussex Genome Damage & Stability Centre and external partners the group has a developing portfolio of novel programs targeting DNA damage repair targets.

Neuroscience – the group has a strong track record in neuroscience drug discovery and has several programs ranging from early hit to lead to late stage optimisation for indications including schizophrenia, pain and anxiety.

Respiratory –  activities are focused upon diseases associated with epithelial dysfunction including cystic fibrosis, COPD and asthma.

Ion channels – the group has considerable expertise in prosecuting ion channel targets and has specialist capabilities including electrophysiology and bespoke compound library generation.

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Principal Disease Indication(s)

Oncology, Neuroscience, Respiratory


Structure-based drug discovery, Ion channel modulators


Biophysical, X-ray crystallography, virtual screening, high-throughput electrophysiology, automated synthesis, medicinal chemistry

Funding sources:

Wellcome Trust, Cancer Research UK, Medical Research Council, EU, Migraine Research Foundation, Alzheimer’s Trust, Janssen, Evotec, Essen, Novartis



Number of Screens / year (any size):


Medicinal Chemistry Follow-up:


Contact Details

Dr Paul Beswick

Phone: +44 (0)1273 873 155

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Getting there

Address: Biology Road, Falmer, Brighton, The City of Brighton and Hove BN1, UK
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